期刊论文

Study on the intervention of integrated traditional Chinese and Western medicine therapy in patients with hepatitis B virus-related acute-on-chronic liver failure

中文

中西医结合肝病杂志

1005-0264

2019

29

3

203-207

10.3969/j.issn.1005-0264.2019.03.004

No.2018ZX10725506-002:国家传染病防治科技重大专项 2012ZX10005-005:国家传染病防治科技重大专项

本校为其他机构

目的:比较中西医结合治疗与单纯西药治疗方案对48周乙型肝炎病毒(HBV)相关慢加急性肝衰竭(ACLF)患者病死率的影响.方法:934例HBV-ACLF患者为研究对象,按照实际接受的治疗方案分为中西医结合治疗组(593例)、西药治疗组(341例),采用Kaplan-Meier方法及log-rank检验比较两组患者4、8、12、24、48周终点事件累积发生率,通过Cox比例风险回归计算分析影响HBV ACLF预后的独立因素.结果:中西医结合治疗组患者4、8、12、24、48周病死率分别为11.6％、17.9％、20.6％、24.5％、27.0％,显著低于西药治疗组的19.1％、25.5％、27.3％、31.4％、32.0％ (P ＜0.05);经校正混杂因素后,中西医结合治疗组患者4、8、...

Objective:To investigate the effects of the integrated Traditional Chinese Medicine(TCM) for the treatment of hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).Methods:We performed an analysis of the "Study on HBV-ACLF treated with integrated Traditional Chinese Medicine and western medicine". According to the actual therapy, HBV-ACLF patients were divided into the TCM group and the western medicine(WM) group. Compared the 48-week mortality rate of patients in the two groups. The t-test or the Mann-Whitney U test was used for comparison of continuous data between groups;the ch...