Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

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成果类型：

期刊论文

作者：

Liu, Mengsi;Zhang, Zhen;Chen, Yating;Feng, Ting;Zhou, Qing;...

通讯作者：

Tian, XF

作者机构：

[Tian, Xuefei; Tian, XF; Chen, Yating; Liu, Mengsi; Feng, Ting] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Tian, Xuefei; Tian, XF; Chen, Yating; Liu, Mengsi; Feng, Ting] Hunan Univ Chinese Med, Hunan Key Lab Tradit Chinese Med Prescript & Syndr, Changsha, Peoples R China.

[Tian, Xuefei; Tian, XF; Chen, Yating; Liu, Mengsi; Feng, Ting] Hunan Prov Univ Key Lab Oncol Tradit Chinese Med, Changsha, Peoples R China.

[Tian, Xuefei; Tian, XF; Chen, Yating; Liu, Mengsi; Feng, Ting] Hunan Univ Chinese Med, Key Lab Tradit Chinese Med Mech Tumor Prevent & Tr, Changsha, Peoples R China.

[Zhang, Zhen] Hunan Acad Tradit Chinese Med, Dept Oncol, Affiliated Hosp, Changsha, Peoples R China.

通讯机构：

[Tian, XF ] H

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Hunan Key Lab Tradit Chinese Med Prescript & Syndr, Changsha, Peoples R China.

Hunan Prov Univ Key Lab Oncol Tradit Chinese Med, Changsha, Peoples R China.

Hunan Univ Chinese Med, Key Lab Tradit Chinese Med Mech Tumor Prevent & Tr, Changsha, Peoples R China.

语种：

英文

关键词：

SREBP;cancer;circadian clock;fatty acid synthetic;lipid metabolism

期刊：

FRONTIERS IN ENDOCRINOLOGY

ISSN：

1664-2392

年：

2023

卷：

页码：

1292011

DOI：

10.3389/fendo.2023.1292011

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors gratefully acknowledge the financial support from the Key projects supported by, National Natural Sciences Foundation of China (82074450), Key scientific research project of Hunan Education Department (grant number 21A0243), Key project of academician workstation guidance project (grant number 21YS003), National Natural Science Foundation of China (U20A20408).

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Recent research has emphasized the interaction between the circadian clock and lipid metabolism, particularly in relation to tumors. This review aims to explore how the circadian clock regulates lipid metabolism and its impact on carcinogenesis. Specifically, targeting key enzymes involved in fatty acid synthesis (SREBP, ACLY, ACC, FASN, and SCD) has been identified as a potential strategy for cancer therapy. By disrupting these enzymes, it may be possible to inhibit tumor growth by interfering with lipid metabolism. Transcription factors, like SREBP play a significant role in regulating fatty...

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Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

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