Identification of Robust Biomarkers for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With House Dust Mite-Induced Allergic Rhinitis by Multiple Cytokine Profiling

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成果类型：

期刊论文

作者：

Xie, Shaobing;Fan, Ruohao;Tang, Qingping;Cai, Xiao;Zhang, Hua;...

通讯作者：

Jiang, Weihong

作者机构：

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Cai, Xiao; Zhang, Hua; Wang, Fengjun; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, Changsha, Peoples R China.

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Cai, Xiao; Zhang, Hua; Wang, Fengjun; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Xiangya Hosp, Hunan Prov Key Lab Otolaryngol Crit Dis, Changsha, Peoples R China.

[Fan, Ruohao; Xie, Shumin; Gao, Kelei; Xie, Shaobing; Cai, Xiao; Zhang, Hua; Wang, Fengjun; Zhang, Junyi; Xie, Zhihai; Jiang, Weihong] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

[Tang, Qingping] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Rehabil, Changsha, Peoples R China.

通讯机构：

[Jiang, Weihong] C

Cent South Univ, Xiangya Hosp, Dept Otolaryngol Head & Neck Surg, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Hunan Prov Key Lab Otolaryngol Crit Dis, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

语种：

英文

关键词：

allergic rhinitis;biomarker;children;cytokine;subcutaneous immunotherapy

期刊：

Frontiers in Immunology

ISSN：

1664-3224

年：

2022

卷：

页码：

805404

DOI：

10.3389/fimmu.2021.805404

基金类别：

This work was supported by National Natural Science Foundation of China (No. 81770985, No. 81800917 and No. 81873695), Natural Science Foundation of Hunan Province (No.2020JJ4910).

机构署名：

本校为其他机构

院系归属：

针灸推拿与康复学院

摘要：

Background: Subcutaneous immunotherapy (SCIT) is an effective treatment for children with allergic rhinitis (AR), but its efficacy fluctuates among patients. There are no reliable candidate biomarkers for monitoring and predicting the response to SCIT. The present study aims to identify novel biomarkers for early predicting the efficacy of SCIT in pediatric AR patients based on multiple cytokine profiling. Methods: We prospectively recruited 72 children with house dust mite (HDM)-induced AR who were assigned to receive SCIT. The serum samples w...

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Identification of Robust Biomarkers for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With House Dust Mite-Induced Allergic Rhinitis by Multiple Cytokine Profiling

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