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Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Kailin*;Zeng, Liuting;Zeng, Jinsong;Deng, Ying;Wang, Shanshan;...

通讯作者：

Yang, Kailin;Ge, JW;Zeng, LT

作者机构：

[Wang, Shanshan; He, Qi; Yang, Kailin; Ge, Jinwen] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

[Yang, Kailin; Ge, Jinwen] Hunan Acad Chinese Med, Changsha, Hunan, Peoples R China.

[Zeng, Liuting; Zeng, LT] Chinese Acad Med Sci & Peking Union Med Coll, Nanjing Drum Tower Hosp, Grad Sch, Peking Union Med Coll,Dept Rheumatol & Immunol, Nanjing, Peoples R China.

[Zeng, Jinsong; Ge, Anqi] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[He, Qi; Deng, Ying] Peoples Hosp Ningxiang City, Ningxiang, Peoples R China.

通讯机构：

[Zeng, LT ] C

[Yang, KL; Ge, JW ] H

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Nanjing Drum Tower Hosp, Grad Sch, Peking Union Med Coll,Dept Rheumatol & Immunol, Nanjing, Peoples R China.

语种：

英文

关键词：

Ferroptosis;Lipid peroxidation;Natural plant products;Oxidative stress;Parkinson's disease

期刊：

Ageing Research Reviews

ISSN：

1568-1637

年：

2023

卷：

页码：

102063

DOI：

10.1016/j.arr.2023.102063

基金类别：

National Natural Science Foundation of China [81774174]; National Key Research and Development Project of China [2018YFC1704904]; Hunan Provincial Natural Science Foundation of China [2020JJ5424]; Hunan University of Chinese Medicine "Double First-Class" Discipline Open Fund Project of Integrated Traditional Chinese and Western Medicine [2020ZXYJH08]; Hunan Provincial Department of Education Youth Fund Project [21B30386]; Provincial Discipline Construction Project of Hunan University of Chinese Medicine (Integrated Traditional Chinese and Western Medicine); Postgraduate Scientific Research Innovation Project of Hunan Province [CX20230800]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the central nervous system after Alzheimer's disease. The current understanding of PD focuses mainly on the loss of dopamine neurons in the substantia nigra region of the midbrain, which is attributed to factors such as oxidative stress, alpha-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction. These factors together contribute to the PD phenotype. Recent studies on PD pathology have introduced a new form of cell death known as ferroptosis. Pathological changes closely linked with ferroptos...

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