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Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged overall survival, and it inhibits cells proliferation while promotes cells apoptosis in epithelial ovarian cancer

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成果类型:
期刊论文
作者:
Luo, Ling;Gao, Yuqiang;Sun, Xiaofeng*
通讯作者:
Sun, Xiaofeng
作者机构:
[Luo, Ling] Cent South Univ, Dept Orthoped, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.
[Gao, Yuqiang] Zaozhuang Municipal Hosp, Dept Clin Lab, Zaozhuang, Shandong, Peoples R China.
[Sun, Xiaofeng] Hunan Univ Chinese Med, Dept Histol & Embryol, Hunan Acad Chinese Med, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Sun, Xiaofeng] H
Hunan Univ Chinese Med, Dept Histol & Embryol, Hunan Acad Chinese Med, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
Circ-ITCH;Epithelial ovarian cancer;cells apoptosis;cells proliferation;overall survival
期刊:
Cancer Biomarkers
ISSN:
1574-0153
年:
2018
卷:
23
期:
4
页码:
505-513
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774362, 81303004]
机构署名:
本校为通讯机构
院系归属:
医学院
中医学院
摘要:
OBJECTIVE: The aim of this study was to evaluate the correlation of circular RNA itchy E3 ubiquitin protein ligase (Circ-ITCH) expression with clinicopathological features and survival in patients with epithelial ovarian cancer (EOC), and to explore its effect on cells proliferation as well as apoptosis in EOC cells. METHODS: Seventy-seven EOC patients underwent surgery were retrospectively reviewed. Tumor tissues and paired adjacent tissues samples were collected, and Circ-ITCH expression was evaluated by quantitative polymerase chain reaction...

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