Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-alpha Pathway Activity in Mice

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期刊论文

作者：

Wang, Chun;Xu, Can-Xin;Krager, Stacey L.;Bottum, Kathleen M.;Liao, Duan-Fang;...

通讯作者：

Tischkau, Shelley A.

作者机构：

[Tischkau, Shelley A.; Wang, Chun; Xu, Can-Xin] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA.

[Wang, Chun; Xu, Can-Xin] Univ S China, Coll Pharm & Life Sci, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Krager, Stacey L.; Bottum, Kathleen M.] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL USA.

[Liao, Duan-Fang] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Tischkau, Shelley A.] 801 N Rutledge,Room 3354,POB 9629, Springfield, IL 62974 USA.

通讯机构：

[Tischkau, Shelley A.] 8

801 N Rutledge,Room 3354,POB 9629, Springfield, IL 62974 USA.

语种：

英文

关键词：

aryl hydrocarbon receptor;BMAL1;circadian rhythm;diabetes;dioxins;PPAR-alpha

期刊：

ENVIRONMENTAL HEALTH PERSPECTIVES

ISSN：

0091-6765

年：

2011

卷：

119

期：

页码：

1739-1744

DOI：

10.1289/ehp.1103593

基金类别：

National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [ES017774]; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES017774, R01ES017774, R01ES017774, R01ES017774, R01ES017774] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

BACKGROUND: Numerous man-made pollutants activate the aryl hydrocarbon receptor (AhR) and are risk factors for type 2 diabetes. AhR signaling also affects molecular clock genes to influence glucose metabolism. OBJECTIVE: We investigated mechanisms by which AhR activation affects glucose metabolism. METHODS: Glucose tolerance, insulin resistance, and expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and genes affecting glucose metabolism or fatty acid oxidation and clock gene rhythms were investigated in wild-type (WT) and AhR-deficient [knockout (KO)] mice. AhR agonis...

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Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-alpha Pathway Activity in Mice

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