Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

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成果类型：

期刊论文

作者：

Xu, C-X;Wang, C.;Zhang, Z-M;Jaeger, C. D.;Krager, S. L.;...

通讯作者：

Tischkau, S. A.

作者机构：

[Wang, C.; Zhang, Z-M; Jaeger, C. D.; Xu, C-X; Tischkau, S. A.] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62702 USA.

[Zhang, Z-M] First Peoples Hosp Chenzhou, Inst Translat Med, Dept Anesthesiol, Chenzhou, Peoples R China.

[Bottum, K. M.; Krager, S. L.] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62702 USA.

[Liu, J.] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang, Peoples R China.

[Liao, D-F] Hunan Univ Tradit Chinese Med, Coll Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

通讯机构：

[Tischkau, S. A.] S

So Illinois Univ, Sch Med, Dept Pharmacol, 801N Rutledge St, Springfield, IL 62702 USA.

语种：

英文

期刊：

International Journal of Obesity

ISSN：

0307-0565

年：

2015

卷：

期：

页码：

1300-1309

DOI：

10.1038/ijo.2015.63

基金类别：

NIEHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [ES017774]; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES017774, R01ES017774, R01ES017774, R01ES017774, R01ES017774] Funding Source: NIH RePORTER

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本校为其他机构

院系归属：

医学院

药学院

摘要：

Background/Objectives:Epidemics of obesity and diabetes are escalating. High-calorie/high-fat food is a major cause for these global health issues, but molecular mechanisms underlying high-fat, diet-induced obesity are still not well understood. The aryl hydrocarbon receptor (AhR), a transcription factor that acts as a xenobiotic sensor, mediates environmental toxicant-induced obesity, insulin resistance and development of diabetes. AhR also influences lipid metabolism and diet-induced obesity. The effects of AhR deficiency on diet-induced obes...

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Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

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