The pharmacological properties of Ophiocordyceps xuefengensis revealed by transcriptome analysis

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成果类型：

期刊论文

作者：

Jin, Jian;Kang, Wenli;Zhong, Can;Qin, You;Zhou, Rongrong;...

通讯作者：

Qin, Yuhui;Zhang, SH

作者机构：

[Liu, Hao; Zhang, Shuihan; Kang, Wenli; Qin, Yuhui; Xie, Jing; Jin, Jian; Chen, Lin; Zhang, SH; Qin, You; Zhong, Can] Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha 410013, Hunan, Peoples R China.

[Jin, Jian; Qin, You; Qin, Yuhui] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Zhong, Can] Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China.

[Zhou, Rongrong] Changchun Univ Chinese Med, Changchun 130117, Jilin, Peoples R China.

[Liu, Hao; Zhang, Shuihan; Xie, Jing; Chen, Lin] 2011 Collaborat & Innovat Ctr Digital Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Qin, YH; Zhang, SH ] H

Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

antineoplastic agent;cisplatin;cordycepin;Ophiocordyceps xuefengensis extract;plant extract;transcriptome;unclassified drug;antineoplastic agent;A-549 cell line;antineoplastic activity;Article;biosynthesis;controlled study;Cordyceps;DNA library;Eca-109 cell line;gene expression;gene ontology;HeLa cell line;Hep-G2 cell line;high performance liquid chromatography;HT-29 cell line;human;human cell;in vitro study;MCF-7 cell line;nonhuman;Ophiocordyceps;Ophiocordyceps xuefengensis;Raji cell line;RNA isolation;transcriptomics;animal;cell proliferation;Chinese medicine;drug effect;gene expression profiling;genetics;isolation and purification;physiology;procedures;trends;A549 Cells;Animals;Antineoplastic Agents;Cell Proliferation;Cordyceps;Gene Expression Profiling;HeLa Cells;Hep G2 Cells;HT29 Cells;Humans;MCF-7 Cells;Medicine, Chinese Traditional

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2018

卷：

219

页码：

195-201

DOI：

10.1016/j.jep.2018.02.007

基金类别：

We thank Mr. Minghe Huang for the help of sample collection and Hunan Engineering Research Center of Anti-tumor TCM Creation & Technology for technical support. This work is supported by the National Natural Science Foundation of China (No. 81673585), the Natural Science Foundation of Hunan Province (No. 2018JJ3309), Hunan Administration of traditional Chinese Medicine (Nos. 201322 and 201762) and Program of Survey and Monitoring of Chinese Medicines for National Drugs ([2011]76). We thank Mr. Minghe Huang for the help of sample collection and Hunan Engineering Research Center of Anti-tumor TCM Creation & Technology for technical support. This work is supported by the National Natural Science Foundation of China (No. 81673585 ), the Natural Science Foundation of Hunan Province (No. 2018JJ3309 ), Hunan Administration of traditional Chinese Medicine (Nos. 201322 and 201762 ) and Program of Survey and Monitoring of Chinese Medicines for National Drugs ( [2011]76 ).

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摘要：

Ethnopharmacological relevance: The Yao ethnic group in Xuefeng Mountains area have used Xuefeng cordyceps, the caterpillar–fungus complex of Ophiocordyceps xuefengensis, for treating a variety of diseases for long. Just like some other cordyceps, O. xuefengensis, which is identified as the sister taxon of O. sinensis in 2013, also seems to have broad pharmacological properties, not only enhancing human immunity, anti–bacteria, anti–virus, but also anti–tumor. However, investigation of the medicinal fugal species O. xuefengensis can be foun...

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The pharmacological properties of Ophiocordyceps xuefengensis revealed by transcriptome analysis

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