miR-19a-3p affected ox-LDL-induced SDC-1/TGF-& beta;1/Smad3 pathway in atherosclerosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jin, Qiao;Deng, Yiming;Li, Liang;Chen, Ran*;Jiang, Luping

通讯作者：

Chen, Ran;Jiang, LP

作者机构：

[Chen, Ran; Deng, Yiming; Li, Liang; Jin, Qiao; Jiang, Luping; Jiang, LP; Chen, R] Univ South China, Changsha Cent Affiliated Hosp, Hengyang Med Sch, Dept Cardiovasc Med, Changsha 410004, Hunan, Peoples R China.

[Jin, Qiao] Cent South Univ, Dept Cardiovasc Med, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[Deng, Yiming] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Jiang, LP ; Chen, R] U

Univ South China, Changsha Cent Affiliated Hosp, Hengyang Med Sch, Dept Cardiovasc Med, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

cerebral infarction;cell viability;inflammation;apoptosis

期刊：

Cellular and Molecular Biology

ISSN：

0145-5680

年：

2023

卷：

期：

页码：

75-81

DOI：

10.14715/cmb/2023.69.3.10

基金类别：

Scientific Research Fund of Hunan Provincial Health Commission [B20182018]

机构署名：

本校为其他机构

院系归属：

研究生院

摘要：

Syndecan-1 (SDC-1) was a critical membrane proteoglycan and an important component of the glycocalyx in endothelial cells, but its role in atherosclerosis remains unknown. This study attempted to investigate the role of SDC-1 in atherosclerotic-related endothelial cell injury. Bioinformatics analyzed the differential miRNAs between atherosclerosis and healthy. Subjects with coronary atherosclerosis, which were diagnosed with intravascular atherosclerosis (IVUS), were enrolled as non-vulnerable plaque and vulnerable plaque in Changsha Central Hospital. Human aortic endothelial cells (HAECs) wer...

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miR-19a-3p affected ox-LDL-induced SDC-1/TGF-& beta;1/Smad3 pathway in atherosclerosis

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