Study on the treatment of postmenopausal osteoporosis with quercetin in Liuwei Dihuang Pill based on network pharmacology

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Fuping;Li, Wuping;Wang, Linhua;Dai, Bing;Liu, Zongyi;...

通讯作者：

Ting Deng

作者机构：

[Liu, Zongyi; Li, Wuping; Zhu, Fuping; Wu, Hang] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Foot & Ankle Orthoped, Changsha, Peoples R China.

[Wang, Linhua] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Extrem & Arthrosis, Changsha, Peoples R China.

[Dai, Bing] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Pharm, Changsha, Peoples R China.

[Deng, Ting] Second Xiangya Hosp Cent South Univ, Clin Nursing Teaching & Res Sect, 139,Renmin Rd, Changsha, Hunan, Peoples R China.

通讯机构：

[Ting Deng] C

Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, China

语种：

英文

关键词：

Postmenopausal osteoporosis;Quercetin;PI3K/AKT signaling;PPI

期刊：

Journal of Orthopaedic Surgery and Research

ISSN：

1749-799X

年：

2023

卷：

期：

页码：

1-12

DOI：

10.1186/s13018-022-03470-1

基金类别：

This work was supported by the Provincial Central Administration Project (E2022008) and the Key Project of Hunan Provincial Department of Education (21A0227).

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

药学院

摘要：

Liuwei Dihuang Pill (LP) was verified to alleviate postmenopausal osteoporosis (PMOP) development. Nevertheless, the major constituent of LP and the related network pharmacology study remain unexplored. Protein–protein interaction was established to identify the downstream target of LP in PMOP, and the related signaling pathway was investigated by bioinformatics analysis. MC3T3-E1 cells were added to ferric ammonium citrate (FAC) to mimic osteoporosis in vitro. The osteoblasts were identified by Alizarin red staining. Western blot was applied ...

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Study on the treatment of postmenopausal osteoporosis with quercetin in Liuwei Dihuang Pill based on network pharmacology

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