期刊论文

中文

新中医

0256-7415

2019

51

5

1-3

10.13457/j.cnki.jncm.2019.05.001

30772824:国家自然科学基金 81574031:国家自然科学基金 2017TP1018:湖南省重点实验室建设项目 K1501014-31:长沙市科技计划 kc1704005:长沙市科技计划 ZK1801YK015:国家中医药管理局中医药重点学科建设

本校为第一机构

目的:探讨兔视网膜中央静脉阻塞(Central retinal vein occlusion,CRVO)模型中小胶质细胞的数量和形态变化及引起变化的机制.方法:将30只成年兔随机分为空白组和模型组,以氩激光照射视网膜主干静脉的方法造模,行眼底照相和眼底荧光素造影(Fundus fluorescein angiography,FFA)检查,分别于1天、3天、7天、14天和28天检测视神经的白细胞分化抗原45(Cluster of differentiation 45,CD45)表达情况.40倍光镜照相,测定灰度值和累计光密度值(IOD值).结果:与空白组比较,模型组3天时CD45表达到达高峰(P ＜0.05),其后模型组CD45表达逐步下降,但仍有小胶质细胞活化.结论:CRVO可以引起视神经的小胶质细胞活化...

Objective:To study the changes in the number and morphology of microglial cells in the central retinal vein occlusion (CRVO) model rabbits and the mechanism of the changes. Methods:Divided 30 rabbits randomly into the blank group and the model group. The argon laser was used to irradiate the main vein of retina to make models. Performed fundus photography and fundus fluorescein angiography (FFA), respectively, on 1, 3, 7, 14, and 28 days of treatment so as to detect the expression of cluster of differentiation 45 (CD45) of the optic nerve, and ...