期刊论文

The Comparison of the Effects of Astregalus Root (HuangQi) andHuoXueFang on Free Radicals and Calcium in Rabbit CeredralIschamic-postischemic Reperfusion injury

中文

中药药理与临床

1001-859X

1994

5

29-32

国家自然科学基金

本校为第一机构

用四血管夹闭模型法建立家兔脑缺血再灌注损伤模型，在脑缺血30分钟和再灌注45分钟后，血浆和脑组织MDA含量明显升高，脑组织GSH—Px活性降低和Ca含量升高。在造摸前分别静注黄芪3．3g／kg、活血方2．5g／kg和由黄芘与活血方组成的益气活血方4．4g／kg后，均可显著抑制再灌注损伤后脑组织MDA含量的升高．提高脑组织GSH—Px活性，但对血浆MDA及脑组织Ca含量均无明显影响，黄芪和活血方台用并无协同作用。提示益气活血方抗脑缺血再灌注损伤的机理与抑制脑组织局部脂质过氧化反应，提高抗氧化酶活性有关，其作用是由其中的黄芪和活血方综合发挥的。

he medel of rabbit cerebral ischemic-postischemic reperfusion injury was made by using four vessel occlusion.Malondtal dehyde (MDA) contentS in plasma and MDA contents and calcium (Ca) contents in brain tissues markedlyincreased and glutathione peroxidase (GSH-Px) activites in brain tissues significantly lowered in 30 minutes ischemiaand 4o minute reperfusion. After intravenous injection of Astregalus toot extracts (3. 3g/kg)、 HuoXueFang (2. 5g/kg) and YiQiHuoXueFang (4.4g/kg) made of Astregalus root and HuoXueFang before ischemia. the increas...