期刊论文

中文

中药药理与临床

1001-859X

1999

15

5

3-6

10.3969/j.issn.1001-859X.1999.05.002

国家自然科学基金

本校为第一机构

目的：比较研究补阳还五汤和其有效部位组方抗脑缺血后ＤＮＤ 作用与脑组织能量代谢、ＮＯ 和ＮＯＳ 的关系。方法：采用沙鼠双侧颈总动脉夹闭脑缺血再灌注模型，于再灌注后４８ 小时取前脑皮质测定Ｎａ ＋Ｋ＋ＡＴＰ 酶、Ｃａ２ ＋ＡＴＰ 酶、Ｍｇ２ ＋ＡＴＰ 酶、乳酸、ＮＯ 和ＮＯＳ。结果：缺血再灌注后４８ 小时脑组织Ｎａ＋Ｋ＋ＡＴＰ酶、Ｃａ２ ＋ＡＴＰ 酶及Ｍｇ２ ＋ＡＴＰ 酶活性均降低，ＮＯ 含量和ＮＯＳ 活性降低，而乳酸含量无明显变化。补阳还五汤和有效部位组方ｉｐ 均可防止缺血再灌注４８ 小时后Ｎａ＋Ｋ＋ＡＴＰ 酶活性的降低，增加ＮＯ 含量，提高ＮＯ...

Objective: Effect of Bu Yang Huan Wu Tang (BYHWT) and its available composition combination antagonisming delayed neuronal death (DND) induced by cerebral ischemia and relation between DND and cerebral tissue energy metabolism, nitric oxide (NO) and nitric oxide synthase (NOS) will be studied. Method: cerebral ischemia model was made by ligating bilateral arteries carotis communis for 20 min followed reperfusion 48h in gerbils. Na + K + ATPase activity, lactic acid content, Ca 2+ ATPase, Mg 2+ ATPase activity, NO content and NOS activity were determined in fore brain cortex at 48h after reperf...