期刊论文

中文

中药药理与临床

1001-859X

2016

32

5

74-78

10.13412/j.cnki.zyyl.2016.05.019

湖南省社会发展支撑类项目（2014SK3058）；

本校为第一机构

探讨莪蚕健胃方调控胃癌前病变大鼠HIF-1ɑ、VEGF蛋白及其mRNA对血管生成的影响。方法:60只Wistar雄鼠分为正常组5只,造模组55只。用MNNG、脱氧胆酸钠等刺激24周制作胃癌前病变模型。确认造模成功后,将造模组随机分为5组,包括模型组,维甲酸组、莪蚕健胃方(8.05g/kg组、16.10g/kg组、32.20g/kg组),每组10只,给药16周后处死取材。观察大鼠病理组织,进行MVD计数,以及HIF-1ɑ、VEGF蛋白和mRNA的检测。结果:与正常组比较,造模组的MVD值和HIF-1ɑ、VEGF蛋白和mRNA的表达均明显升高,且随异型增生程度加重而增强(两两比较P

To investigate the effects on angiogenesis from Ecan Jianwei recipe regulating precancerous lesions rats' HIF-1ɑ,VEGF's protein and mRNA.Methods: 60 male Wistar rats were divided into normal group with 5 rats and module group with 55 rats. Using MNNG, sodium desoxycholate and other stimulations for 24 weeks to make gastric precancerous lesion model. After confirming the success of the model, the model group was randomly divided into 5 groups, including model group,retinoic acid treatment group,Ecan Jianwei recipe (group 8.05g/kg,group 16.10g/k...