期刊论文

Effects of Baishile Capsule on Nerve Regeneration in Hippocampal Septo-temporal Axis of Depressive Rats

中文

中药药理与临床

1001-859X

2018

34

3

169-172

10.13412/j.cnki.zyyl.2018.03.041

国家自然科学基金青年项目（81403387） 国家科技重大专项课题（2017ZX09309026） 中医内科学省部共建教育部重点实验室开放基金（ZYNK201503） 湖南省教育厅优秀青年资助项目（17B201）

本校为第一机构

目的:探讨百事乐胶囊对慢性应激抑郁模型大鼠海马隔颞轴神经再生的影响。方法:将50只雄性SD大鼠随机分为空白对照组、抑郁模型组、氟西汀(5.4 mg /kg)组、百事乐胶囊高、低剂量(2.88、0.72 g /kg)组,每组10只。采用慢性不可预见性温和应激建立抑郁大鼠模型,连续应激21天,每组一半的大鼠在造模前腹腔注射BrdU(75mg /kg) ,另一半大鼠在处死前2h腹腔注射BrdU(100mg /kg) ,采用糖水偏好实验测试大鼠的抑郁样行为;采用免疫荧光双染技术观察大鼠海马隔颞轴Brdu、Brdu + NeuN、 Brdu + DCX、Brdu + GFAP蛋白表达的变化。结果:与空白组比较,模型组大鼠糖水偏食度显著降低;隔颞轴BrdU标记的新生神经细胞及...

Objective: To investigate the effect of Baishile capsule on nerve regeneration in hippocampal septo-temporal axis of depressive rats. Methods: 50 SD rats were randomly divided into the control group,depression model group,fluoxetine (5.4 mg /kg) group and high,medium and low doses of Baishile capsule (2.88、0.72 g /kg) . The depression model was established by chronic unpredictable mild stress for 21 days. Half of rats in each group were intraperitoneally injected with BrdU (75 mg /kg) before molding,and the other half were intraperitoneally in...