期刊论文

Anti Artery Thrombosis and Anti Venous Thrombosis Effect of Jateorhizine on Rats

中文

中药药理与临床

1001-859X

2020

36

02

126-132

10.13412/j.cnki.zyyl.2020.02.003

湖南省教育厅科学研究项目（编号:16B192）；

本校为第一机构

目的:探讨药根碱对大鼠动、静脉血栓形成的作用,并分析其是否会导致出血倾向。方法:采用体外凝血实验,检测药根碱对家兔血浆凝血四项活化部分凝血酶原时间( APTT) 、凝血酶原时间( PT) 、凝血酶时间( TT)的影响;采用大鼠FeCl_3诱导的颈总动脉血栓模型和下腔静脉结扎静脉血栓模型,检测血栓形成阻塞时间( OT) 、血栓重量、凝血、抗凝及纤溶等相关指标,分析药根碱对血栓形成的影响;小鼠尾静脉给药后,测定出血时间,初步分析药根碱是否存在导致出血的风险。结果: ①体外实验表明,药根碱在浓度0.4 mg /ml ~ 1.2 mg /ml呈浓度依赖地延长APTT(P < 0.01), 但不延长PT和TT(P > 0.05) 。②在大鼠颈总动脉、...

Objective: To investigate the effect of jatrorrhizine on arteriovenous thrombosis in rats,and to analyze its bleeding tendency. Methods: In vitro coagulation test was used to observe the effects of jatrorrhizine on the activated partial thromboplastin time( APTT), prothrombin time ( PT) and thrombin time( TT) in rabbit plasma. Then the common carotid artery thrombosis rat model induced by FeCl_3 and venous thrombosis model caused by ligating the inferiorvena cava were established to detect thrombosis occlusion time ( OT), thrombus weight,coagul...