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Rapid screening of the antithrombotic active components of Agrimonia pilosa Ledeb with thrombin binding affinity ultrafiltration mass spectroscopy

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成果类型:
期刊论文
作者:
Dai, Jie;He, Weihe;Liu, Shi Ao;Huang, Shiyi;He, Xiangchang;...
通讯作者:
Xu, GM
作者机构:
[Dai, Jie; Huang, Shiyi; Liu, Shi Ao; Zhao, Hongqing; Zou, Ting; He, Xiangchang; He, Weihe; Xu, Guangming] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.
通讯机构:
[Xu, GM ] H
Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.
语种:
英文
期刊:
ANALYTICAL METHODS
ISSN:
1759-9660
年:
2025
卷:
17
期:
9
页码:
2046-2058
基金类别:
Hunan Provincial Natural Science Foundation Project [2021JJ30511]; Key Scientific Research Project of Hunan Province Education Department research [24A0276]; College student Innovation and Entrepreneurship training plan of Hunan Province [S202410541075]
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
Traditional Chinese Medicine (TCM) holds significant potential as a natural source of medication, providing effective alternatives for preventing and treating thrombotic diseases. Although research on the anticoagulant activity of Agrimonia Pilosa Ledeb (Rosaceae, A. pilosa) has been paid attention to, the monomer component and its mechanism of action have not been studied deeply. Therefore, this study aimed to screen and identify the antithrombotic active components of A. pilosa by affinity ultrafiltration (AUF) combined with ultra-high performance liquid chromatography-quadrupole time-of-fli...

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