The Significant Role of the Microfilament System in Tumors

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成果类型：

期刊论文

作者：

Jiang, Xin;Qin, Yiming;Kun, Liu;Zhou, Yanhong

作者机构：

[Zhou, Yanhong; Jiang, Xin; Qin, Yiming] Cent South Univ, Hunan Canc Hosp, NHC Key Lab Carcinogenesis, Xiangya Sch Med, Changsha, Peoples R China.

[Zhou, Yanhong; Jiang, Xin; Qin, Yiming] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China.

[Zhou, Yanhong; Jiang, Xin; Qin, Yiming] Cent South Univ, Canc Res Inst, Basic Sch Med, Changsha, Peoples R China.

[Kun, Liu] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Neurosurg, Sch Clin Med, Changsha, Peoples R China.

语种：

英文

关键词：

Microfilament system;Actin skeleton;Cancer;ARP2/3;anticancer drugs

期刊：

Frontiers in Oncology

ISSN：

2234-943X

年：

2021

卷：

页码：

620390

DOI：

10.3389/fonc.2021.620390

基金类别：

This paper was supported and conducted by the National Natural Sciences Foundation of China [grant number 81672685] and the Science and Technology Foundation Survey Project of Ministry of Science and Technology of China [grant numbers 2018FY100900 and 2018FY10090004].

机构署名：

本校为其他机构

院系归属：

临床医学院

摘要：

Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer and polymer. Among them, monomer actin is a spherical molecule composed of a polypeptide chain, also known as spherical actin. The function of actin polymers is to produce actin filaments, so it is also called fibroactin. The actin cytoskeleton is considered to be an important subcellular filament system. It interacts with numerous relevant proteins and regulatory cells, regulating basic functions, from cell division and muscle contraction to cell movement and ensuring tissue integrity. The dynamic r...

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The Significant Role of the Microfilament System in Tumors

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