Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress

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成果类型：

期刊论文

作者：

Wang, Yanli;Chen, Tian;Shi, Zhe;Dong, Lijinchuan;Li, Mengting;...

通讯作者：

Wang, YL;Hu, Q

作者机构：

[Wang, Yanli; Li, Qi; Peng, Bo; Chen, Ying; Dong, Lijinchuan; Li, Mengting; Hu, Qin; Wang, YL; Xiao, Shuiming; Yang, Qing] China Acad Chinese Med Sci, Inst Chinese Mat Med, 16 Dongzhimen Nei Nanxiao Rd, Beijing 100700, Peoples R China.

[Chen, Tian; Hu, Q; Hu, Qin] Beijing Univ Technol, Coll Chem & Life Sci, 100 Pingleyuan Rd, Beijing 100124, Peoples R China.

[Shi, Zhe] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Peoples R China.

[Jiang, Ning; Liu, Xinmin] Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China.

[Liu, Xinmin] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315000, Peoples R China.

通讯机构：

[Hu, Q ] B

[Wang, YL ] C

China Acad Chinese Med Sci, Inst Chinese Mat Med, 16 Dongzhimen Nei Nanxiao Rd, Beijing 100700, Peoples R China.

Beijing Univ Technol, Coll Chem & Life Sci, 100 Pingleyuan Rd, Beijing 100124, Peoples R China.

语种：

英文

关键词：

ginseng total saponins;gastrointestinal microbiome;immunity;short-chain fatty acids;weightlessness simulation

期刊：

Drug Design, Development and Therapy

ISSN：

1177-8881

年：

2025

卷：

页码：

1289-1303

DOI：

10.2147/DDDT.S486371

基金类别：

National Natural Science Foundation of China [82074103]; Space Engineering Space Medical Experiment Field Program of China [HYZHXM05003]; Major Science and Technology Project in the Autonomous Region [2023A02010-3]; Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences [CI2021A04905, CI2021B015]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

BACKGROUND: Duringmedium- to long-duration spaceflights, real-time microgravity can increase the health risks of astronauts. In particular, the disruption of intestinal homeostasis is closely related to other health problems, and it is necessary to monitor related treatment strategies. Ginseng is a well-known Chinese herbal medicine often used to maintain health. Ginseng total saponins (GTSs), which are the bioactive components of ginseng, have been reported to regulate immune homeostasis, anti-inflammation, and anti-oxidation. This study focused on the regulation of GTSs in intestinal homeost...

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Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress

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