期刊论文

中文

中西医结合心脑血管病杂志

1672-1349

2004

2

12

715-717

10.3969/j.issn.1672-1349.2004.12.022

湖南省教育厅科研项目

本校为第一机构

目的探讨养心通脉液对心肌缺血再灌注损伤(CIRI)冠状微循环的影响及其作用机制.方法对养心通脉注射液治疗组、复方丹参注射液治疗组、CIRI模型组和假手术组4组的心肌毛细血管墨汁灌流数、大鼠冠状微循环荧光变化时间及心肌组织MDA、NO、Na+-K+ATPase、Ca2+-ATPase、血清CK活性、血浆TXB2和6-K-PGF1α含量进行检测和相关分析.结果与CIRI模型组比较,养心通脉组大鼠显示:①原缺血部位心肌毛细血管墨汁灌流数有明显增加,其荧光饱和时间(ST)和荧光出现时间(AT)均明显缩短(P＜0.05或P＜0.01);②心肌组织MDA含量下降,Na+K+-ATPase、Ca2+-ATPase活性均提高,血清CK水平下降,心肌组织NO的含量升高,血浆6-K...

Objective To study the effects and the mechanism of Yangxin-Tongmai (YXTM) injection on Coronary Microcirculation of Rats with Cardial Reperfusion Injury (CIRI).Methods To the following four groups: CIRI cured (YXTM)by injection group, CIRI cured by compound Danshen (CDS) injection group, the CIRI model group and pretending operation group of rats, We detected the number of myocardial capillaries perfused with ink, the time spans of fluorescence in rat's coronary microcirculation, the content of the myocardial maloncliddehyde (MDA) and the myoc...