期刊论文

The Influence and Significance of Sini Decoction on Experimental Hyperlipidemia Combined with Atherosclerosis in Rabbit Model

中文

实用中医内科杂志

1671-7813

2012

26

7

1-3+6

10.3969/j.issn.1671-7813.2012.07.01

长沙市科技计划重点项目（k1005020-31） 湖南省教育厅项目（NO：06C629）

本校为第一机构

[目的]观察四逆汤预干预对高脂血症(HLP)合并动脉粥样硬化(AS)兔的TC、TG、HDL-CH、LDL-CH、Apo-A、Apo-B的影响,分析其对高脂血症(HLP)合并动脉粥样硬化(AS)兔血脂及载脂蛋白的调节作用.[方法]通过高脂饲料喂养及免疫损伤法建立兔HLP合并AS模型,分别给予西药(阿托伐他汀)和四逆汤(高、中、低剂量)的治疗方法.运用酶法测定血中TC、TG含量的变化；比色法测定干预后血中LDL-CH、HDL-CH含量的变化；电泳法测干预后血中载脂蛋白A及B含量的变化.[结果]四逆汤中、高剂量组在降低血TG含量与模型组比具有统计学意义(P＜0.05)；四逆汤高剂量组在降低血TC、LDL、Apo-B含量与模型组比具有统计学意义(P＜0.0...

[ Objective ] To observe the effect on TC ,TG,HDL.LDL,Apo - A,Apo - B of HLP combined AS rabbits treated by Sini Decoction, and to analyze the regulatingeffect on blood lipid and apolipoprotein of this therapy. [Method]While fed with high fat food everyday and injected with BSA, egg -white protein, HLP combined AS rabbits were treated with different way of Atorvastatin and three doses of Sini Decoction （ High, middle and low）. To observe the changes after the intervention of the use of enzymatic determination of serum TC, TG, NO level ; color...