RAB22A overexpression promotes the tumor growth of melanoma

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成果类型：

期刊论文

作者：

Su, Feng;Chen, Yifei;Zhu, Shilin;Li, Fangfang;Zhao, Shuang;...

通讯作者：

Su, Juan

作者机构：

[Su, Feng] Cent S Univ, Xiangya Hosp, Dept Emergency, Changsha, Hunan, Peoples R China.

[Chen, Yifei] Cent S Univ, Xiangya Hosp, Dept Pharm, Changsha, Hunan, Peoples R China.

[Zhu, Shilin] Hunan Univ TCM, Affiliated Hosp 2, Dept Neurol, Changsha, Hunan, Peoples R China.

[Zhao, Shuang; Su, Juan; Li, Fangfang; Chen, Xiang] Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.

[Zhao, Shuang; Su, Juan; Li, Fangfang; Chen, Xiang] Cent S Univ, Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China.

通讯机构：

[Su, Juan] C

Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

melanoma;RAB22A;prognosis;malignant phenotype;microRNA

期刊：

Oncotarget

ISSN：

1949-2553

年：

2016

卷：

期：

页码：

71744-71753

DOI：

10.18632/oncotarget.12329

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81472882]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

Malignant melanoma is the most aggressive type of skin cancer. RAB22A, a member of RAS oncogene family, has been found to be significantly upregulated in multiple human cancers. In the present study, we found that RAB22A mRNA expression was significantly upregulated in melanoma tissues (including 60 primary melanomas and 84 metastatic melanomas) compared to benign nevi (n = 20), which were significantly higher in metastatic melanoma tissues than primary tissues. Immunohistochemistry data further showed that the positive immunoreactivity of RAB22A was detected in 66% (95/144) melanoma tissues, ...

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RAB22A overexpression promotes the tumor growth of melanoma

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