Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

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成果类型：

期刊论文

作者：

Song, Houpan;Hou, Xueqin;Zeng, Meiyan;Chen, Xiaojuan;Chen, Xinyi;...

通讯作者：

Yu, R;Cai, X

作者机构：

[Cai, Xiong; Chen, Xiaojuan; Chen, Xinyi; Yang, Tao; Peng, Jun; Peng, Qinghua; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Hou, Xueqin] Shandong First Med Univ & Shandong Acad Med Sci, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China.

[Chen, Xiaojuan; Chen, Xinyi; Yu, Rong; Zeng, Meiyan; Yu, R] Hunan Univ Chinese Med, Hunan Prov Key Lab Translat Res TCM Prescript & Z, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Xu, Fuping] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China.

[Cai, Xiong; Cai, X] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Cai, X ; Yu, R ] H

Hunan Univ Chinese Med, Hunan Prov Key Lab Translat Res TCM Prescript & Z, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

antiulcer agent;esomeprazole;herbaceous agent;li zhong tang;malonaldehyde;myeloid differentiation factor 88;nitric oxide;prostaglandin E2;toll like receptor 2;tumor necrosis factor;unclassified drug;antiulcer agent;autacoid;cytokine;herbaceous agent;indometacin;Myd88 protein, rat;myeloid differentiation factor 88;Tlr2 protein, rat;toll like receptor 2;yijung-tang;animal experiment;animal model;Article;chemical composition;Chinese medicine;controlled study;drug mechanism;drug structure;epithelium cell;evaluation study;histopathology;immunofluorescence;immunohistochemistry;indomethacin-induced gastric ulcer;male;mucosal immunity;necrosis;nonhuman;protein expression;rat;real time polymerase chain reaction;regulatory mechanism;scoring system;signal transduction;single drug dose;stomach acid secretion;stomach hemorrhage;stomach juice;stomach mucosa;stomach pH;ulcer healing rate;ulcer index;Western blotting;animal;disease model;drug effect;genetics;immunology;metabolism;oxidative stress;pathology;Sprague Dawley rat;stomach ulcer;time factor;wound healing;Animals;Anti-Ulcer Agents;Cytokines;Disease Models, Animal;Drugs, Chinese Herbal;Gastric Mucosa;Immunity, Mucosal;Indomethacin;Inflammation Mediators;Male;Myeloid Differentiation Factor 88;Oxidative Stress;Rats, Sprague-Dawley;Signal Transduction;Stomach Ulcer;Time Factors;Toll-Like Receptor 2;Wound Healing

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2020

卷：

259

页码：

112979

DOI：

10.1016/j.jep.2020.112979

基金类别：

This study was funded by grants from the National Natural Science Foundation of China (no. 81703920 to SHP, no. 81804150 to PJ, and no. 81703901 to HXQ), China Postdoctoral Science Foundation (no. 2019M662790 to SHP), Hunan Provincial Natural Science Foundation (no. 2019JJ50442 to SHP and no. 2018JJ2293 to CX), National Key R & D Program of China (nos. 2018YFC1704300 and 2018YFC1704400 to YR), Scientific Research Project of Hunan Traditional Chinese Medicine Administration (no. 201780 to SHP), Hunan Education Department's Science & Research Project (no. 19C1426 to ZMY and no. 17K069 to CX), Research-based Learning and Innovative Experiment Program Project for Hunan University Students (no. 2017280 to SHP), Open-ended Science Foundation of the National First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine (no. 2018ZYX20 to ZMY and no. 2018ZYX26 to SHP), Open-ended Science Foundation of Institute of Innovation and Applied Research in Chinese Medicine (no. 201903 to CX), and was supported by the Hunan Provincial 121 Training Project for Innovative Talents. This study was funded by grants from the National Natural Science Foundation of China (no. 81703920 to SHP, no. 81804150 to PJ, and no. 81703901 to HXQ), China Postdoctoral Science Foundation (no. 2019M662790 to SHP), Hunan Provincial Natural Science Foundation (no. 2019JJ50442 to SHP and no. 2018JJ2293 to CX), National Key R & D Program of China (nos. 2018YFC1704300 and 2018YFC1704400 to YR), Scientific Research Project of Hunan Traditional Chinese Medicine Administration (no. 201780 to SHP), Hunan Education Department's Science & Research Project (no. 19C1426 to ZMY and no. 17K069 to CX), Research-based Learning and Innovative Experiment Program Project for Hunan University Students (no. 2017280 to SHP), Open-ended Science Foundation of the National First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine (no. 2018ZYX20 to ZMY and no. 2018ZYX26 to SHP), Open-ended Science Foundation of Institute of Innovation and Applied Research in Chinese Medicine (no. 201903 to CX), and was supported by the Hunan Provincial 121 Training Project for Innovative Talents .

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摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Li-Zhong-Tang (LZT) is a well-known Chinese herbal formulation first described in one of traditional Chinese medicine (TCM) scriptures, Treatise on Febrile Diseases. LZT has been commonly prescribed for the treatment of various gastrointestinal diseases for over 1800 years, and has demonstrated pronounced therapeutic effects on patients with gastric ulcers. AIM OF THE STUDY: The present study aimed to scientifically evaluate protective effects of LZT on indomethacin (IND)-induced gastric injury in rats and to elu...

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Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

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