Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

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成果类型：

期刊论文

作者：

Song, Houpan;Hou, Xueqin;Zeng, Meiyan;Chen, Xiaojuan;Chen, Xinyi;...

通讯作者：

Yu, Rong;Cai, Xiong

作者机构：

[Cai, Xiong; Chen, Xiaojuan; Chen, Xinyi; Yang, Tao; Peng, Jun; Peng, Qinghua; Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Hou, Xueqin] Shandong First Med Univ & Shandong Acad Med Sci, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China.

[Chen, Xiaojuan; Chen, Xinyi; Yu, Rong; Zeng, Meiyan] Hunan Univ Chinese Med, Hunan Prov Key Lab Translat Res TCM Prescript & Z, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Xu, Fuping] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Guangdong, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Yu, Rong; Cai, Xiong] H

Hunan Univ Chinese Med, Hunan Prov Key Lab Translat Res TCM Prescript & Z, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Gastric ulcer;Li-Zhong-Tang;Prostaglandin;Cytokines;TLR-2;MyD88

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2020

卷：

259

页码：

112979-

DOI：

10.1016/j.jep.2020.112979

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81703920, 81804150, 81703901]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M662790]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ50442, 2018JJ2293]; National Key R&D Program of China [2018YFC1704300, 2018YFC1704400]; Scientific Research Project of Hunan Traditional Chinese Medicine Administration [201780]; Hunan Education Department's Science & Research Project [19C1426, 17K069]; Research-based Learning and Innovative Experiment Program Project for Hunan University Students [2017280]; Openended Science Foundation of the National First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine [2018ZYX20, 2018ZYX26]; Open-ended Science Foundation of Institute of Innovation and Applied Research in Chinese Medicine [201903]; Hunan Provincial 121 Training Project for Innovative Talents

机构署名：

本校为第一且通讯机构

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Li-Zhong-Tang (LZT) is a well-known Chinese herbal formulation first described in one of traditional Chinese medicine (TCM) scriptures, Treatise on Febrile Diseases. LZT has been commonly prescribed for the treatment of various gastrointestinal diseases for over 1800 years, and has demonstrated pronounced therapeutic effects on patients with gastric ulcers. AIM OF THE STUDY: The present study aimed to scientifically evaluate protective effects of LZT on indomethacin (IND)-induced gastric injury in rats and to elu...

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Traditional Chinese Medicine Li-Zhong-Tang accelerates the healing of indomethacin-induced gastric ulcers in rats by affecting TLR-2/MyD88 signaling pathway

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