Traditional Chinese Medicine formula Bu-Shen-Huo-Xue-Fang (BSHXF) protects nucleus pulposus cells against the inflammatory and oxidative stress-induced degenerative changes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Linghui;Wei, Xu;Li, Kaiming;Gong, Hao;Zhu, Liguo*;...

通讯作者：

Zhu, Liguo;Yang, SF

作者机构：

[Zhan, Jiawen; Wang, Shangquan; Li, Linghui; Sun, Wu; Chen, Ming; Yang, Shaofeng; Chen, Xin; Li, Kaiming; Zhu, Liguo; Yu, Jie; Gu, Jinyu; Feng, Minshan; Yin, Xunlu] China Acad Chinese Med Sci, Wangjing Hosp, Dept Gen Orthoped, Huajiadi St, Beijing 100102, Peoples R China.

[Wei, Xu] China Acad Chinese Med Sci, Wangjing Hosp, Dept Acad Dev, Huajiadi St, Beijing 100102, Peoples R China.

[Gong, Hao] Changping Hosp Integrated Chinese & Western Med, Dept Orthopaed, 219 Huangping St, Beijing 102208, Peoples R China.

[Yang, Shaofeng] Hunan Univ Chinese Med, Dept Spine, Hosp 1, Changsha 410007, Peoples R China.

通讯机构：

[Yang, SF ; Zhu, LG] C

China Acad Chinese Med Sci, Wangjing Hosp, Dept Gen Orthoped, Huajiadi St, Beijing 100102, Peoples R China.

Hunan Univ Chinese Med, Dept Spine, Hosp 1, Changsha 410007, Peoples R China.

语种：

英文

关键词：

Nucleus pulposus cells (NPCs);Senescence;Intervertebral disc degeneration (IDD);Bu-Shen-Huo-Xue-Fang (BSHXF);Aucubin;Tanshinol

期刊：

Journal of Pharmaceutical and Biomedical Analysis

ISSN：

0731-7085

年：

2023

卷：

236

页码：

115656

DOI：

10.1016/j.jpba.2023.115656

基金类别：

National Natural Science Foundation of China [81904230, 81804120, 81302992, 81674005]

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

Degeneration of the intervertebral disc is primarily caused by the loss of nucleus pulposus cells (NPCs) and extracellular matrix (ECM) (IDD). Bu-Shen-Huo-Xue-Fang (BSHXF), a traditional Chinese medicine decoction, has been used to treat IDD in clinical; nevertheless, the active components and underlying molecular mechanisms remain unknown. BSHXF improved IL-113 and H2O2 stimulation-induced injuries on NPCs by promoting cell viability, increasing ECM deposition, inhibiting cell senescence, and decreasing the levels of inflammatory factors. The active ingredients in BSHXF were identified by LC-...

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Traditional Chinese Medicine formula Bu-Shen-Huo-Xue-Fang (BSHXF) protects nucleus pulposus cells against the inflammatory and oxidative stress-induced degenerative changes

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