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The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment

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成果类型:
期刊论文
作者:
Xie, Haihua;Jiang, Jia;Cao, Sihui;Xu, Xuan;Zhou, Jingyin;...
通讯作者:
Peng, Liang;Liu, M
作者机构:
[Xie, Haihua; Liu, Mi; Peng, Liang; Huang, Bo; Liu, M; Cao, Sihui; Jiang, Jia; Xu, Xuan; Zhou, Jingyin; Lu, Penghui; Zhang, Ruhan] Hunan Univ Chinese Med, Sch Acupuncture & Tuina & Rehabil, Changsha 410208, Peoples R China.
通讯机构:
[Peng, L; Liu, M ] H
Hunan Univ Chinese Med, Sch Acupuncture & Tuina & Rehabil, Changsha 410208, Peoples R China.
语种:
英文
关键词:
trimethylamine-N-oxide;mild cognitive impairment;gut microbiota;metabolism;brain disease;risk factor;mechanism;therapy
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2025
卷:
26
期:
3
页码:
1373-
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 82174521), projects of the Science and Technology Innovation Plan in Hunan Province (No. 2024JK2132, No. 2024RC1061), the Project of Chinese Medicine Research in Hunan Province (No. C2022027), the State Administration of Traditional Chinese Medicine 2022 Youth Qihuang Scholars Training Program (National Letter of Traditional Chinese Medicine Education [2022] 256), the Hunan Provincial Graduate Joint Cultivation Base for Acupuncture-Moxibustion and Tuina of Hunan University of Chinese Medicine (No. [2022] 357, Hunan Provincial Department of Education Notice), the Acupuncture Bioinformation and Smart Wellness Innovation and Entrepreneurship Education Center of Hunan University of Chinese Medicine (No. [2021] 356, Hunan Provincial Department of Education Notice), and the Innovative Graduate Cultivation Base for Chinese Medicine Sub-health of Hunan University of Chinese Medicine (No. [2020] 19, University Administrative Research Document).
机构署名:
本校为第一且通讯机构
摘要:
Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia, often considered critical for dementia prevention. Despite its significance, no effective clinical treatment for MCI has yet been established. Emerging evidence has demonstrated a strong association between trimethylamine-N-oxide (TMAO), a prominent metabolite derived from the gut microbiota, and MCI, highlighting its potential as a biomarker and therapeutic target. TMAO has been implicated in increasing MCI risk through its influence on factors s...

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