The combination of astragaloside IV and Panax notoginseng saponins attenuates cerebral ischaemia–reperfusion injury in rats through ferroptosis and inflammation inhibition via activating Nrf2
[Wang, Linlin; Xiao, Lan; Kang, Zhineng; Xiao, Qian; Tang, Biao] Hunan Univ Chinese Med, Basic Res Ctr Integrated Chinese & Western Med Pre, Changsha, Peoples R China.
[Tang, Biao] Hunan Univ Chinese Med, Med Sch, Xiangzui Rd, Changsha, Hunan, Peoples R China.
通讯机构：
[Biao Tang] B
Basic Research Center of Integrated Chinese & Western Medicine for Prevention & Treatment of Vascular Diseases, Hunan University of Chinese Medicine , Changsha , China
National Natural Science Foundation of China [81503385]; Hunan Provincial Natural Science Foundation of China [2021JJ30505]; National Training Programs of Innovation and Entrepreneurship for Undergraduates [202210541132]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
OBJECTIVES: This study aimed to observe the effect of the combination of astragaloside IV (AST IV) and Panax notoginseng saponins (PNS) on cerebral ischaemia-reperfusion injury (CIRI) and explore the specific mechanism of the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated combination of AST IV and PNS against CIRI based on ferroptosis and inflammatory response. METHODS: The therapeutic effect and mechanism of AST IV and PNS were evaluated by constructing a Sprague-Dawley rat middle cerebral artery ischaemia-occlusion-reperfusion mo...
