Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats

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成果类型：

期刊论文

作者：

Li, Zi-Rong;Liu, De-Guo;Xie, Sheng;Wang, Yu-Hong;Han, Yuan-Shan;...

通讯作者：

Sheng Xie<&wdkj&>Yu-Hong Wang

作者机构：

[Li, Zi-Rong] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Neurol, Nanning 530022, Guangxi, Peoples R China.

[Liu, De-Guo] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Breast Surg, Nanning 530022, Guangxi, Peoples R China.

[Xie, Sheng] Guangxi Univ Chinese Med, Affiliated Hosp 1, Prevent Dis Tradit Chinese Med Ctr, Nanning 530022, Guangxi, Peoples R China.

[Li, Chun-Yan; Wang, Yu-Hong; Zou, Man-Shu] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hun, Changsha 410208, Hunan, Peoples R China.

[Han, Yuan-Shan] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Expt, Ctr Med Innovat, Changsha 410021, Hunan, Peoples R China.

通讯机构：

[Sheng Xie] P

[Yu-Hong Wang] S

Prevention of Diseases with Traditional Chinese Medicine Center, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, Nanning, 530022, China<&wdkj&>State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (incubation), Hunan University of Chinese Medicine, Hunan, Changsha, 410208, China

语种：

英文

关键词：

Depressive insomnia comorbidity;Chronic mild unpredictable stress;Sleep deprivation;Synaptic plasticity;Melatonin

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2022

卷：

930

页码：

175149

DOI：

10.1016/j.ejphar.2022.175149

基金类别：

National Natural Science Foundation of China [81573965]; Guangxi Postdoctoral Special Funding Project, Research Project of the First Affiliated Hospital of Guangxi University of Chinese Medicine [202113]; Guangxi Provincial Education Department Scientific Research Project [2022KY0267]; Guangxi University of Chinese Medicine [2021BS030]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

药学院

摘要：

There has been ample research showing that insomnia is a potential trigger of depression as well as a symptom of depression. These two factors contribute to behavioural problems and are closely related to the plasticity of hippocampal synapses. Although depression and insomnia impair hippocampal synaptic plasticity, the mechanism by which this happens remains a mystery. This study aimed to investigate the pathogenesis of insomnia comorbidity in depression and the regulatory effect of venlafaxine combined with melatonin on hippocampal synaptic plasticity in chronic unpredictable mild stress (CU...

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Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats

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