期刊论文

Effects of Ligustrazine Extracts on the Levels of Plasma TXB2 and 6-Keto-PGF1α after Focal Cerebral Ischemia in Rats

中文

血栓与止血学

1009-6213

2009

15

6

246-248

10.3969/j.issn.1009-6213.2009.06.002

湖南省自然科学基金资助项目（08JJ4008） 湖南省教育厅科研基金重点项目（07A050） 湖南省教育厅科研基金青年项目（068068）.

本校为第一机构

目的 本实验旨在揭示大鼠脑缺血再灌注后川芎嗪对其血浆血栓素B2(TXB2)及6-酮-前列腺素F1a(6-Keto-PGF1α)含量的影响.方法 线栓大鼠左侧大脑中动脉制作大鼠脑缺血再灌注模型,15只健康SD大鼠随机分为假手术组、模型组和川芎嗪组.观察川芎嗪治疗7天后血浆TXB2和 6-Keto-PGF1α含量的变化.结果 模型组术后血浆TXB2含量和TXB2/6-Keto-PGF1α比值明显高于假手术组(p< 0.01),经川芎嗪治疗后,血浆TXB2含量和TXB2/6-Keto-PGF1α明显降低(p< 0.01)了,与假手术组比较无统计学差异(p> 0.05).结论 川芎嗪能通过降低血浆TXB2及TXB2/6-Keto-PGF1α,达到对脑缺血再灌注大鼠的神经保护作用.

Objective The mechanisms of ligustrazine effects on focal cerebral ischemia were studied by observing the levels of thromboxane B2（TXB2） and 6-keto- rostaglandinF1α（6-Keto-PGF1α）. Methods 15 Sprague-Dawley （SD） rats were randomly divided into the sham operation group, the model group, and ligus-trazine group. 7 days after operation, the contents of plasma TXB2 and -Keto-PGF1α were detected by radioim- munoassay method. Results Compared to those in the sham operation group, plasma TXB2 level and TXB2/ 6-keto-PGF1α ratio markedly increa...