Dissecting the effects of paraquat-induced pulmonary injury in rats using UPLC-Q-TOF-MS/MS-based metabonomics

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成果类型：

期刊论文

作者：

Liu, Xiehong;Li, Chi;Hou, Changmiao;Jiang, Yu;Chen, Fang;...

通讯作者：

Zou, LH

作者机构：

[Li, Chi; Chen, Fang; Zou, Lianhong; Zhu, Yimin; Hou, Changmiao; Liu, Xiehong; Jiang, Yu] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, 61 Jiefang West Rd, Changsha 410005, Hunan, Peoples R China.

[Li, Chi; Chen, Fang; Zou, Lianhong; Zhu, Yimin; Hou, Changmiao; Liu, Xiehong; Jiang, Yu] Hunan Prov Key Lab Emergency & Crit Care Metabon, 61 Jiefang West Rd, Changsha 410005, Hunan, Peoples R China.

[Li, Chi; Chen, Fang; Zou, Lianhong; Zhu, Yimin; Hou, Changmiao; Liu, Xiehong; Jiang, Yu] Hunan Provinicial Inst Emergency Med, 61 Jiefang West Rd, Changsha 410005, Hunan, Peoples R China.

[Hou, Changmiao] Hunan Univ Chinese Med, Sch Clin Med, 113 Shaoshan Middle Rd, Changsha 410000, Hunan, Peoples R China.

[Zou, Lianhong] Hunan Normal Univ, Hunan Prov Peoples Hosp, Hunan Prov Inst Emergency Med, Affiliated Hosp 1, 61 Jiefang West Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Zou, LH ] H

Hunan Normal Univ, Hunan Prov Peoples Hosp, Hunan Prov Inst Emergency Med, Affiliated Hosp 1, 61 Jiefang West Rd, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

paraquat;metabolomics;UPLC-Q-TOF-MS/MS;inflammation;pulmonary fibrosis

期刊：

Toxicology Research

ISSN：

2045-452X

年：

2023

卷：

期：

页码：

527-538

DOI：

10.1093/toxres/tfad040

机构署名：

本校为其他机构

院系归属：

临床医学院

摘要：

Objective Paraquat (PQ) is a toxic compound that selectively accumulates in the lungs, inducing severe pulmonary inflammation and fibrosis. However, data on the metabolomic changes induced by the PQ remain scant. This study aimed to determine the metabolic changes in Sprague-Dawley rats subjected to PQ using UPLC-Q-TOF-MS/MS. Methods We established groups of PQ-induced pulmonary injury rats for 14 or 28 days. Results Our data showed that PQ decreased the survival of the rats and induced pulmonary inflammation at day 14 or pulmonary fibrosis at day 28. There was upregulation of IL-1 beta expres...

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Dissecting the effects of paraquat-induced pulmonary injury in rats using UPLC-Q-TOF-MS/MS-based metabonomics

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