Epigenetic regulation of melanogenesis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Shihang;Zeng, Hongliang;Huang, Jinhua;Lei, Li;Tong, Xiaoliang;...

通讯作者：

Chen, Jing;Zeng, QH

作者机构：

[Huang, Jinhua; Luo, Liping; Tong, Xiaoliang; Zeng, Qinghai; Zeng, QH; Li, Si; Zhou, Shihang; Zhou, Ying; Lei, Li; Guo, Haoran; Chen, Jing; Khan, Manal] Cent South Univ, Xiangya Hosp 4, Dept Dermatol, Changsha 410013, Hunan, Peoples R China.

[Zeng, Hongliang] Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha 410013, Hunan, Peoples R China.

[Xiao, Rong] Cent South Univ, Hunan Key Lab Med Epigenet, Second Xiangya Hosp, Dept Dermatol, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Chen, J; Zeng, QH ] C

Cent South Univ, Xiangya Hosp 4, Dept Dermatol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Chromatin remodelers;DNA methylation;Epigenetics;Histone modification;Melanogenesis;Noncoding RNAs

期刊：

Ageing Research Reviews

ISSN：

1568-1637

年：

2021

卷：

页码：

101349

DOI：

10.1016/j.arr.2021.101349

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 82073420 ) and the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hosipital of Central South University ( YX202007 ).

机构署名：

本校为其他机构

摘要：

Melanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides. DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT) and microphthalmia-associated transcription factor (MITF), as well as paracrine fa...

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