期刊论文、会议论文

中文

中华中医药杂志

1673-1727

2015

30

5

1708-1711

第六届全国中医药博士生学术论坛

第六届全国中医药博士生学术论坛论文集

2015-04-01

福州

中华中医药学会

湖南省高校创新平台开放基金项目（N o.11K048） 湖南省研究生科研创新项目（N o.CX2013B329）

本校为第一机构

目的:研究芎麻汤药效部位对硝酸甘油所致偏头痛大鼠行为学症状、血浆及脑组织中三叉神经颈髓复合体(TCC)上5-羟色胺(5-HT)的影响,初步探讨其药效部位的作用机制。方法:32只雄性SD大鼠随机分为空白组(A组),模型组(B组),芎麻汤药效部位组(C组),琥珀酸舒马普坦阳性对照组(D组),每组8只;采用皮下注射硝酸甘油(10mg/kg)复制偏头痛模型,观察大鼠挠头、爬笼、咬尾、往返运动,取颈外静脉血采用ELISA检测血浆中5-HT含量,心脏灌注后取大鼠TCC采用免疫组化检测5-HT的阳性表达。结果:芎麻汤药效部位能有效减轻偏头痛大鼠行为学症状,有效降低偏头痛大鼠血浆中5-HT含量,有效降低偏头痛大鼠TCC内5-HT免疫阳性染...

　　Objective: To study the effects of active extracts of Xiongma Decoction on behavioral symptoms and levels of5-HT in plasma and trigeminocervical complex (TCC) on animal model of migraine with Nitroglycerin.Methods: Thrity-two SD rats were randomly divided into 4 groups: blank group (group A), model group (group B), Xiongma Decoction group (group C), and sumatriptan group (group D).The migraine model was established by giving hypodermic injection of 10mg/kg Nitroglycerin, the scratching, climbing, biting, back and forth movement were observe...