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Potential mechanisms underlying the therapeutic roles of sinisan formula in depression: Based on network pharmacology and molecular docking study

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成果类型:
期刊论文
作者:
Wang, Hui;Liu, Jiaqin;He, Jinbiao;Huang, Dengxia;Xi, Yujiang;...
作者机构:
[Wang, Hui; Chen, Xudong] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Peoples R China.
[Xi, Yujiang; Wang, Hui; Zhang, Shiwei; He, Jinbiao; Huang, Dengxia; Wan, Siyan] Yunnan Univ Tradit Chinese Med, Kunming, Peoples R China.
[Liu, Jiaqin] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China.
[Liu, Jiaqin] Cent South Univ, Inst Clin Pharm, Changsha, Peoples R China.
[Xiao, Ting] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.
语种:
英文
关键词:
sinisan formula;depression;network pharmacology;molecular docking;neurotransmitter-related mechanisms
期刊:
Frontiers in Psychiatry
ISSN:
1664-0640
年:
2022
卷:
13
基金类别:
National Natural Science Foundation of China; Natural Science Foundation of Hunan Province of China; Yunnan Provincial Education Department Scientific Research Fund Project; [82201662]; [2020JJ5800]; [2021Y471]
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
BackgroundThe incidence of depression has been increasing globally, which has brought a serious burden to society. Sinisan Formula (SNSF), a well-known formula of traditional Chinese medicine (TCM), has been found to demonstrate an antidepressant effect. However, the therapeutic mechanism of this formula remains unclear. Thus, the present study aimed to explore the mechanism of SNSF in depression through network pharmacology combined with molecular docking methods. Materials and methodsBioactive compounds, potential targets of SNSF, and related genes of depression were obtained from public dat...

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