期刊论文

中文

中国现代医学杂志

1005-8982

2011

21

34

4261-4264

10.3969/j.issn.1005-8982.2011.34.009

本校为第一机构

目的 通过急性毒性试验与长期毒性试验验证龙丹腰痹宁的毒理学安全性,为临床用药提供安全参考剂量.方法 ①急性毒性实验:昆明种小鼠40只,随机分成给药组和对照组,采用最大给药量法测定小鼠口服龙丹腰痹宁最大耐受量；②长期毒性实验:根据药效学有效剂量确定长毒实验的低、中、高剂量组,观察连续灌胃给药12周及停药4周后大鼠的生长发育情况,摄食量并检测血常规、血生化指标和主要脏器脏体系数及常规病理检查.结果 小鼠口服龙丹腰痹宁的最大耐受量按生药量计算为427.6g/kg,相当于成人临床每日口服剂量的523.4倍.连续用药90d后大鼠一般体征、血液学各项指标均无明显异常.恢复期一个月后各项指标均无...

[ Objective ] To evaluate the toxicological safety on Longdan Yaobi Ning pellets for clinical reference by acute toxicity test and long-term toxicity test. [Methods]①Classical acute toxicity test： 40 mice were randomly divided into 2 groups to calculate MTD （maximum tolerated dose）. ②Chronic toxicity test： 80 rats were randomly divided into normal, low-dose, moderate-dose and high-dose groups and administrated intragastrieally daily for 12 consecutive weeks. General conditions including bodyweight, diet and behavior were observed daily an...