期刊论文

中文

中国现代医学杂志

1005-8982

2012

22

20

5-8

10.3969/j.issn.1005-8982.2012.20.002

基金项目：国家自然科学基金（No：81072867）

本校为第一机构

目的 观察艾灸中脘、足三里穴对急性胃黏膜损伤模型大鼠胃黏膜上皮HSP60、HSP70表达的影响.方法 32只SD大鼠完全随机分为空白组、模型组、艾灸穴位组和艾灸非穴位组.艾灸预处理大鼠8d无水乙醇灌胃,造急性胃黏膜损伤模型.采用免疫组织化学法检测HSP60、HSP70的表达.结果 与空白组比较,模型组中胃黏膜损伤指数、HSP60表达明显升高(P＜0.01).与模型组和艾灸非穴位组相比,艾灸穴位组胃黏膜损伤指数明显降低(P＜0.01),HSP60、HSP70过度高表达(P＜0.01).结论 艾灸中脘、足三里穴预处理能够降低无水乙醇对胃黏膜的损伤指数,诱导HSP60、HSP70的过度表达,减少伤害性刺激,从而起到保护胃黏膜的作用.艾灸穴...

[Objective] To observe the effects of moxibustion at Zhongwan （RN12） - Zusanli （ST36） on apoptosis of gastric mucosal cells and the expressions of heat shock protein 60 （HSP60） and heat shock protein 70 （HSP70）. [Methods] 32 SD rats were randomly allocated to blank, model, moxibustion acupoint, moxibustion non-acupoint groups with 8 cases in each group. The rats were pre-treated with moxibustion for 8 days. Acute gastric mucosa injury model was established by anhydrous alcohol-induced method. Test apoptotic cells and expression of HSP60...