期刊论文

Gene polymorphism of angiotensin-converting enzyme and susceptibility to chronic heart failure in China

中文

中国循证心血管医学杂志

1674-4055

2020

12

11

1311-1315

10.3969/j.issn.1674-4055.2020.11.08

湖南省自然科学基金(2018JJ6036) 湖南省中医药管理局课题(201641)。

本校为第一机构

目的通过Meta分析评价血管紧张素转换酶（ACE）基因多态性与我国慢性心力衰竭的关联性。方法检索Pub Med、EMbase、CNKI、CBM、VIP和Wan Fang等6大数据库,搜集国内外ACE基因I/D基因多态性与心力衰竭发病风险关联性的病例-对照研究或队列研究,检索时间截止为2019年10月1日;此外,检索纳入文献及相关综述的参考文献,并在Google及百度学术进行检索,补充未纳入上述数据库文献。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险,采用Stata13.0软件进行Meta分析。结果最终纳入13个病例-对照研究,包括纳入心力衰竭患者1524例,健康对照1576例,合计样本量为3100例。Meta分析结果显示,D等位基因...

Objective To analyze and review the relevance between gene polymorphism of angiotensinconverting enzyme(ACE)and chronic heart failure(CHF)in China by applying Meta-analysis.Methods The databases of PubMed,EMbase,CNKI,CBM,VIP and WanFang Data were retrieved for searching the case-control studies or cohort studies on the relevance between gene polymorphism of I/D gene of ACE and CHF at home and abroad,and the deadline was Oct.1,2019.In addition,the references of included literature and related reviews,and Google and Baidu Academic were retrieved for supplementing the documents not included in th...