期刊论文

中文

中国临床研究

1674-8182

2024

37

02

188-191+196

10.13429/j.cnki.cjcr.2024.02.005

本校为第一机构

在肿瘤微环境中,氨基酸是构成免疫细胞和肿瘤细胞的重要营养物质,其代谢过程中的部分蛋白质或关键酶有望成为肿瘤诊断标志物或治疗靶点.研究发现部分氨基酸含量在正常人和胃癌患者中存在明显差异.氨基酸代谢也被证实参与激活PI3K/AKT/mTOR通路,该通路是调节肿瘤细胞生长、增殖、分裂、自噬等活动的主要通路之一,氨基酸代谢可作为信号分子,通过激活该通路相关靶点来影响胃癌的发生发展及转归预后;此外,氨基酸代谢对于免疫细胞的激活和分化有着重要生物学作用,可以通过调控免疫细胞和免疫因子对肿瘤的免疫功能产生影响.

In the tumor microenvironment,amino acids are important nutrients constituting immune cells and tumor cells.Some proteins or key enzymes in the metabolism process are expected to become tumor diagnostic markers or therapeutic targets.It was found that the contents of some amino acids were obviously different between normal people and gastric cancer patients.Amino acid metabolism has also been confirmed to be involved in the activation of the PI3K/AKT/mTOR pathway,which is one of the main pathways regulating the growth,proliferation,division and autophagy of tumor cells.Amino acid metabolism ca...