Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder via regulating gut microbiota and bile acids

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xie, Guozhen;Deng, Na;Zheng, Tao;Peng, Xinxin;Zhang, Shuihan;...

作者机构：

[Xie, Guozhen; Zheng, Tao] Hunan Univ Chinese Med, Sch Pharm, Changsha, Peoples R China.

[Deng, Na] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Peoples R China.

[Peng, Xinxin] Hunan Univ Chinese Med, Hosp 1, Changsha, Peoples R China.

[Zhang, Shuihan] Hunan Acad Chinese Med, Inst Chinese Mat Med, Changsha, Peoples R China.

[Tan, Zhoujin] Hunan Univ Chinese Med, Coll Med, Changsha, Peoples R China.

语种：

英文

关键词：

Total glycosides of Qiwei Baizhu Powder;Gut Microbiota;Bile acid metabolism;Diarrhea;Bioactive component

期刊：

Frontiers in Cellular and Infection Microbiology

ISSN：

2235-2988

年：

2022

卷：

页码：

1207

DOI：

10.3389/fcimb.2022.945263

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Hunan Province; First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine; [81804076]; [2020JJ5426]; [201803]

机构署名：

本校为第一机构

院系归属：

医学院

中医学院

第一中医临床学院

药学院

摘要：

Qiwei Baizhu Powder (QWBZP) is a traditional Chinese medicine formula for treating diarrhea induced by various causes. It elicits an anti-diarrheal effect by regulating the gut microbiota (diversity, structure, and abundance). However, the contribution of different components in the QWBZP decoction to this effect remains unclear. In this study, we used the QWBZP decoction as a reference standard to investigate the effects of total glycosides (TGs) extracted from QWBZP decoction on the gut microbiota and bile acid metabolism in mice with antibiotic-associated diarrhea (AAD). The results of 16S ...

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Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder via regulating gut microbiota and bile acids

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