期刊论文

Impact of butylphthalide on the plasm angiotensin Ⅱ and B - type natnuretic peptide levels of patients with acute mas-sive cerebral infarction

中文

临床合理用药杂志

1674-3296

2015

18

1-2

10.15887/j.cnki.13-1389/r.2015.18.001

本校为第一机构

目的：探讨丁苯酞对急性大面积脑梗死患者血浆血管紧张素Ⅱ（AngⅡ）、B 型脑钠肽（BNP）水平的影响。方法选取湖南省脑科医院2012年1月—2014年6月收治的急性大面积脑梗死患者220例，随机分为非丁苯酞组和丁苯酞组，每组110例。采用美国国立卫生院神经功能缺损评分量表（NIHSS）进行神经功能评估，采取酶联免疫吸附法（ELISA）检测 AngⅡ水平、化学发光免疫分析测定 BNP 水平。结果丁苯酞组患者 NIHSS 评分、血浆 AngⅡ、BNP 水平低于非丁苯酞组，差异有统计学意义（P ﹤0.05）。结论丁苯酞可以通过降低急性大面积脑梗死患者血浆 AngⅡ、BNP 水平而改善其神经功能缺损，起到神经保护作用。

Objective To investigate the impact of butylphthalide on the plasm angiotensin Ⅱ(AngⅡ)and B -type natnuretic peptide(BNP)levels of patients with acute massive cerebral infarction. Methods In Hunan Brain's Hospital from January 2012 to June 2014,a total of 220 patients with acute massive cerebral infarction were selected and randomly divided into the butylphthalide group(n = 110)and the non - butylphthalide group(n = 110). The nerve function were assessed by NIHSS,AngⅡ levels were detected by ELISA,BNP levels were measured by chemiluminescenc...