A New Target of the Four-Herb Chinese Medicine for Wound Repair Promoted by Mitochondrial Metabolism Using Protein Acetylation Analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Zhongzhi;Chen, Li;Su, Yuxin;Li, Meirong;Zhong, Lingzhi;...

通讯作者：

Fu, Xiaobing;He, Wenjun;Hou, Q

作者机构：

[Liao, Liangying; Zhou, Zhongzhi] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Wang, Wei; Yuan, Zhonghang; Ding, Yarong; Chen, Li; Hang, Xinyu; Liu, Mulin; Fang, Xiuna] Hunan Univ Chinese Med, Med Coll, Changsha, Hunan, Peoples R China.

[He, Wenjun; Chen, Li; Zhong, Lingzhi; Fu, Xiaobing; Li, Meirong; Fu, XB; Hou, Qian] Chinese Peoples Liberat Army PLA Gen Hosp, Ctr Wound Healing & Tissue Regenerat, Med Innovat Res Dept, Beijing, Peoples R China.

[Su, Yuxin] Acad Mil Med Sci, Acad Mil Med Sci, Beijing, Peoples R China.

通讯机构：

[He, WJ; Fu, XB; Hou, Q ] C

Chinese Peoples Liberat Army PLA Gen Hosp, Ctr Wound Healing & Tissue Regenerat, Med Innovat Res Dept, Beijing, Peoples R China.

语种：

英文

关键词：

Acetylation;Herbal Medicine;Proteomics;Wound Healing

期刊：

Medical Science Monitor

ISSN：

1643-3750

年：

2022

卷：

页码：

e934816

DOI：

10.12659/MSM.934816

基金类别：

Key Special Projects of National Key Research and Development Plan [2017YFC1104700]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81973862, 82074447]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2020JJ4462]; Hunan Traditional Chinese Medicine Research Project [2020006]; 2017 Provincial Finance Traditional Chinese Medicine Project "Famous Hospital Project" -competitive disease diabetic foot [rsk-010-17]

机构署名：

本校为第一机构

院系归属：

医学院

第一中医临床学院

摘要：

BACKGROUND Wound healing is a dynamic and complex process that is regulated by a variety of factors and pathways. This study sought to identify the mechanisms of the four-herb Chinese medicine ANBP in enhancing wound repair. MATERIAL AND METHODS By comparing the group treated with ANBP for 6 h (Z6h) with the corresponding control group (C6h), we used the new high-throughput differential acetylation proteomics method to explore the mechanism of ANBP treatment and analyse and identify new targets of ANBP for promoting wound healing. RESULTS ANBP promoted skin wound healing in mice; the wound hea...

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A New Target of the Four-Herb Chinese Medicine for Wound Repair Promoted by Mitochondrial Metabolism Using Protein Acetylation Analysis

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