期刊论文、会议论文

You, Z.

中文

中国中药杂志

1001-5302

2010

35

22

3065-3068

中华中医药学会第九次全国中医妇科学术大会

中华中医药学会第九次全国中医妇科学术大会论文集

2009-11-01

广州

中华中医药学会

10.4268/cjcmm20102229

湖南省科技计划重点项目

本校为其他机构

目的:通过研究寿胎丸对小鼠反复自然流产模型Th1/TH_2型细胞因子表达及妊娠结局的影响,探讨寿胎丸在诱导母一胎免疫耐受中的作用机制. 方法:设立正常妊娠组(CBA/J×BALB/c)与反复自然流产组(CBA/J×DBA/2),将反复自然流产组孕鼠按怀孕先后顺序随机分为模型组,寿胎丸低、中、高剂量组,从妊娠第1天开始给药,孕14 d后处死孕鼠,计算各组胚胎吸收率,ELISA检测蜕膜及胎盘组织共培养上清细胞因子IL-4, IL-10, IFN-γ,TNF-α的含量. 结果:模型组的胚胎吸收率模型高于正常妊娠组,寿胎丸中、高剂量能显著降低反复自然流产孕鼠的胚胎吸收率,寿胎丸低、中、高剂量组均可降低反复自然流产小鼠母胎界面IFN-γ和...

OBJECTIVE: To evaluate its mechanism of inducing the maternal-fetal immune tolerance by studying the effects of Shoutai pills on the expression of Th1/Th2 cytokine and pregnancy in maternal-fetal interface of mice with recurrent spontaneous abortion (RSA). METHOD: The normal pregnancy and RSA model were respectively induced with CBA/J x BALB/c and CBA/J x DBA/2. The mice with RSA were randomly divided into model group and low, middle and high dose groups of Shoutai pills. The mice were killed in 14 days after administration and embryo resorption rate was counted and their decidual and placenta...