Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774326]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ2207]
机构署名：
本校为第一且通讯机构
院系归属：
第二中医临床医学院
摘要：
Psoriasis is a chronic inflammatory disease of the skin with highly complex pathogenesis. In this study, we identified lncRNA SPRR2C (small proline-rich protein 2C) as a hub gene with a critical effect on the pathogenesis of psoriasis and response to treatment using both weighted gene coexpression network analysis (WGCNA) and differential expression analysis. SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment. After SPRR2C knockdown, IL-22-induced suppression of H...
