Objective:To provide experimental evidences for choosing murine models in the pathogenesis research of thymic impairment induced by viral infection,we compared the impacts of polycytidylic acid (Poly (I ∶C)) and dexamethasone (DEX) on the thymic morphology and thymic output function,and explored the implication of RLR signaling pathway.Methods:24 male C57BL/6 mice were randomly assigned into three groups and treated with Poly(I ∶C),DEX,or saline respectively.Thereafter,their thymic morphology,pathological changes,thymic index,and thymic patho...