期刊论文

Xu, F

英文

Frontiers in Medicine

2296-858X

2025

11

1492383

10.3389/fmed.2024.1492383

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This paper was funded by Excellent Young Scientist Project of Scientific Research of Hunan Provincial Department of Education (No. 23B0392); General Research Project of Hunan Provincial Administration of Traditional Chinese Medicine (No. B2023010); Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine [202302]. Rong-Rong Wu: 2023 Undergraduate Scientific Research Innovation Fund of Hunan University of Chinese Medicine, Project number (2023BKS120), Research mechanism of pansenoside Rh4 regulating PI3K/AKT pathway remodeling related macrophage polarization inhibiting epithelial mesenchymal transformation of gastric cancer, 2024.01 to 2025.12, 5000 yuan, research in progress, chaired by Yuan Yuan. The university-level research project of Hunan University of Traditional Chinese Medicine (Z2023YYJJ08).

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OBJECTIVES: To explore the mechanism underlying the effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses of the gut microbiota. METHODS: In this study, we randomly divided mice into the control, model, FAE high-dose, FAE medium-dose, and FAE low-dose groups to analyze the pathological changes in the hepatic fibrosis and levels of the α-SMA, collagen 1, Nuclear Factor Kappa B (NF-κ B), Toll Like Receptor 4 (TLR4). The gut microbiota was analyzed throug...