期刊论文

中文

中医儿科杂志

1673-4297

2013

9

5

12-16

湖南省教育厅一般科研资助项目（09C736）；

本校为第一机构

目的 观察观音合剂对肺脾气虚型大鼠模型肺泡灌洗液、肠道黏膜sIgA的影响,探讨观音合剂治疗小儿反复呼吸道感染的疗效及机制.方法 健康SPF级SD大鼠80只随机分为5组,即观音合剂大剂量组、观音合剂小剂量组、脾胺肽对照组、空白对照组、模型对照组,每组16只.3周造模成功后,分别灌胃观音合剂大、小剂量煎剂,脾胺肽和生理盐水,干预30 d后,评价大鼠外观行为学,称脾脏、胸腺质量,计算脾脏、胸腺指数,放射免疫法检测肺泡灌洗液、肠道黏膜sIgA的含量.结果 模型对照组大鼠肺泡灌洗液、肠道黏膜表面sIgA浓度和脾脏(胸腺)质量、指数降低,与空白对照组比较差异有高度统计意义(P＜0.01).观音合剂能改善模型组...

Objective To observe the effect of Guanyin Mixture on the sIgA of bronchoalveolar lavage fluid and intestinal mucosa of lung and spleen deficiency rat model,and investigate deeply into its mechanism of treating pediatric respiratory tract infection.Methods Eighty healthy SD rats（SPF grade） were randomly separated into five groups： normal group,model group,spleen amino peptide group,high-dose Guanyin Mixture group,low-dose Guanyin mixture group,16 rats in each group.After three weeks,the model was made successfully.The animals were respective...