Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways

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成果类型：

期刊论文

作者：

Shao, Qian-hang;Zhang, Xiao-ling;Chen, Ying;Zhu, Cheng-Gen;Shi, Jian-Gong;...

通讯作者：

Yuan, Yu-he;Chen, Nai-hong

作者机构：

[Shao, Qian-hang; Chen, Ying; Shi, Jian-Gong; Chen, Nai-hong; Zhang, Xiao-ling; Yuan, Yu-he; Zhu, Cheng-Gen] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Shao, Qian-hang; Chen, Ying; Shi, Jian-Gong; Chen, Nai-hong; Zhang, Xiao-ling; Yuan, Yu-he; Zhu, Cheng-Gen] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Shao, Qian-hang; Chen, Ying; Shi, Jian-Gong; Chen, Nai-hong; Zhang, Xiao-ling; Yuan, Yu-he; Zhu, Cheng-Gen; Chen, NH] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

[Chen, Nai-hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Yuan, Yu-he; Chen, NH] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

通讯机构：

[Yuan, YH; Chen, NH] P

[Yuan, YH; Chen, NH] C

Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

20C;Autophagy;Mitogen-activated protein kinases (MAPKs);Toll like receptor 4 (TLR4);Protein kinase B (Akt);Mechanistic target of rapamycin (mTOR)

期刊：

Molecular Immunology

ISSN：

0161-5890

年：

2018

卷：

页码：

115-123

DOI：

10.1016/j.molimm.2018.04.014

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773925, U1402221, 81573640, 81373997]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7161011]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

20C, a novel bibenzyl compound, is isolated from Gastrodia elata. In our previous study, 20C showed protective effects on tunicamycin-induced endoplasmic reticulum stress, rotenone-induced apoptosis and rotenone-induced oxidative damage. However, the anti-neuroinflammatory effect of 20C is still with limited acquaintance. The objective of this study was to confirm the anti-neuroinflammatory effect of 20C on Lipopolysaccharide (LPS)-activated BV-2 cells and further elucidated the underlying molecular mechanisms. In this study, 20C significantly ...

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Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways

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