miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Shuai;Yuan, Wei;Luo, Weiwei;Nie, Kai;Wu, Xing;...

通讯作者：

Wang, XY

作者机构：

[Meng, Xiangrui; Luo, Weiwei; Nie, Kai; Wu, Shuai; Wu, Xing; Shen, Zhaohua; Wang, Xiaoyan; Yuan, Wei] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.

[Meng, Xiangrui; Luo, Weiwei; Nie, Kai; Wu, Shuai; Wu, Xing; Shen, Zhaohua; Wang, Xiaoyan; Yuan, Wei] Cent South Univ, Xiangya Hosp 3, Key Lab Nonresolving Inflammat & Canc Hunan Prov, Changsha, Peoples R China.

[Yuan, Wei] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Hepatol, Changsha, Peoples R China.

[Wang, XY] Cent South Univ, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Wang, XY ] C

Cent South Univ, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

colorectal cancer;CXCL12;intestinal epithelial cells;macrophages;miR-126

期刊：

Molecular Oncology

ISSN：

1574-7891

年：

2022

卷：

期：

页码：

3465-3489

DOI：

10.1002/1878-0261.13218

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272736, 81670504, 81472287]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Inflammatory bowel disease, characterised by chronic relapsing-remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR-126 functions as a tumour suppressor in CRC and is inversely correlated with tumour proliferation, metastasis and patient prognosis. In the current study, we documented a protective role for miR-126 in colitis-associated CRC (CAC) and its underlying mechanism. We detected downregulated miR-126 expression during colorectal tumorigenesis in the mouse CAC model and in specimens from patients with CRC. The deficiency of miR-126 i...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问