Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats

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成果类型：

期刊论文

作者：

Chen, Wanyu;Liao, Lu;Huang, Zitong;Lu, Yulin;Lin, Yukang;...

作者机构：

[Huang, Zitong; Yi, Shulin; Huang, Chen; Tan, Bo; Chen, Wanyu; Pei, Ying; Lu, Yulin] Guangzhou Univ Chinese Med, Res Ctr Basic Intergrat Med, Sch Basic Med Sci, Guangzhou, Peoples R China.

[Liao, Lu] Shanghai Univ Tradit Chinese Med, Shenzhen Hosp, Guangzhou, Peoples R China.

[Lin, Yukang] Hunan Univ Chinese Med, Coll Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Cao, Hongying] Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou, Peoples R China.

语种：

英文

关键词：

Patchouli alcohol;Irritable bowel syndrome with diarrhea;colonic longitudinal muscle myenteric plexus;excitatory neurons;intestinal motility

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

4838

DOI：

10.3389/fphar.2022.943119

基金类别：

National Natural Science Foundation of China [8197141628]; Key Project of Department of Education of Guangdong Province [2022ZDZX2019]; "Double First-class" and High-level University Discipline collaborative innovation team project of Guangzhou University of Chinese Medicine [8197141628]; [2021xk37]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Background and Purpose: Irritable bowel syndrome (IBS) is usually associated with chronic gastrointestinal disorders. Its most common subtype is accompanied with diarrhea (IBS-D). The enteric nervous system (ENS) modulates major gastrointestinal motility and functions whose aberration may induce IBS-D. The enteric neurons are susceptible to long-term neurotransmitter level alterations. The patchouli alcohol (PA), extracted from Pogostemonis Herba, has been reported to regulate neurotransmitter release in the ENS, while its effectiveness against IBS-D and the underlying mechanism remain unknown...

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Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats

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