期刊论文

Effect of reinforcing kidney medicinal diet on bone formation in ovariectomized osteoporotic rats

中文

中国骨质疏松杂志

1006-7108

2020

26

3

353-356

10.3969/j.issn.1006-7108.2020.03.009

2018年湖南省研究生科研创新项目,补肾膳食对绝经后骨质疏松症相关症状及血清指标影响的回顾性调研(52)。

本校为第一机构

目的 观察骨形成代谢指标BGP的变化,探讨补肾药膳影响卵巢去势骨质疏松模型大鼠骨形成的机制.方法 将60只SPF级雌性SD大鼠随机分为6组,各组10只,正常组、假手术组、模型空白组等选用一般饲料饲养,高剂量药膳组、低剂量药膳组、骨疏康颗粒组等造模1周后进行灌胃.3个月后取大鼠血清标本以ELISA法检测血清BGP水平.结果 低剂量组与高剂量组与模空组之间差异无统计学意义,但血清BGP具有下降的趋势,骨疏康组血清BGP水平高于模空组(P＜0.05).结论 补肾药膳对卵巢去势绝经后骨质疏松大鼠模型的骨形成代谢指标有一定的改善作用,在改善血清BGP方面弱于BALP、PINP等指标,补肾药膳方影响PMOP症机制值得进一步...

Objective To observe the changes of bone formation metabolic index BGP and to explore the mechanism of the effect of kidney-tonifying herbal diet on bone formation in ovariectomized osteoporotic rats.Methods Sixty SPF female SD rats were randomly divided into 6 groups,with 10 in each group.Rats in normal group,sham-operated group,and model blank group were fed with general diet.Rats in high-dose diet group,low-dose diet group,and Gushukang granule group were fed after 1 week of modeling.Three months later,serum samples of the rats were taken to detect the concentration of BGP using ELISA.Resul...