期刊论文

Study of the mechanism of inhibition of bone resorption with the strong-bone and analgesic prescription through RANKL/RANK signaling pathway

中文

中国骨质疏松杂志

1006-7108

2023

29

09

1333-1339

10.3969/j.issn.1006-7108.2023.09.015

81973160:国家自然科学基金 2021JJ30494:湖南省自然科学基金项目

本校为第一机构

目的探讨壮骨止痛方调控骨吸收及破骨活动干预去势大鼠骨质疏松症的疗效和作用机制,为临床治疗绝经后骨质疏松症提供实验依据。方法40只SD大鼠按照完全随机原则分为ZGZTF组、EV组、OVX组、SHAM组。除SHAM组之外余下...展开更多 目的探讨壮骨止痛方调控骨吸收及破骨活动干预去势大鼠骨质疏松症的疗效和作用机制,为临床治疗绝经后骨质疏松症提供实验依据。方法40只SD大鼠按照完全随机原则分为ZGZTF组、EV组、OVX组、SHAM组。除SHAM组之外余下均按国内外常用PMOP模型构建方法造模。术后第7天分别给予中药、雌二醇和蒸馏水灌胃。末次取材后检测大鼠右侧股骨骨密度,HE染色法观察各组大鼠胫骨骨组织病...

Objective To explore the curative effect and mechanism of the strong-bone and analgesic prescription on interfering with osteoporosis in castrated rats by regulating bone resorption and osteoclastic activity,and to provide a feasible strategy for the clinical treatment ...MORE Objective To explore the curative effect and mechanism of the strong-bone and analgesic prescription on interfering with osteoporosis in castrated rats by regulating bone resorption and osteoclastic activity,and to provide a feasible strategy for the clinical treatment of postmenopausal osteoporosis.Methods Forty SD rats...