期刊论文

Guo, R

英文

Tissue and Cell

0040-8166

2025

93

102682

10.1016/j.tice.2024.102682

source This project was supported by Hunan Provincial Natural Science Foundation (No. 2021JJ31004). CRediT authorship contribution statement Zizhao Tang: Writing – review & editing, Methodology, Investigation, Formal analysis. Youjie Zeng: Writing – review & editing, Validation, Software, Methodology. Ren Guo: Writing – review & editing, Supervision, Project administration, acquisition, Conceptualization. Fangqin Nie: Resources, Methodology, Investigation, Conceptualization. Xia Wang: Writing – original draft, Visualization, Methodology, Investigation, Data curation, Conceptualization. Yu Lv: Writing – original draft,

本校为其他机构

Introduction The phenotypic transition of vascular smooth muscle cells (VSMCs) from a quiescent, contractile type to a secretory phenotype with high proliferation and mobility is a key event in vascular remodeling. PF-477736 is an ATP-competitive inhibitor of Chk1 which induces the accumulation of DNA damage by increasing the level of replicative stress, and ultimately inhibiting cell proliferation or causing cell death. Although this compound has been utilized as an anti-tumor drug, its role in vascular remodeling remains unclear. The phenotyp...